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+This household contains just one protein, SET7/9, which mono-methylates histone at H3K4 ninety two KMT7 was discovered to methylate, besides histone, various non-histone proteins, including p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear issue kappaB (NFκB), and elements of the TATA binding protein (TBP) complicated, TBP-associated factors TAF10 and TAF7 93 The consensus recognition sequence in substrates for SET7-mediated lysine methylation, K/R-S/T-K ([goal lysine](http://service.megaworks.ai/board/bbs/board.php?bo_table=hwang_form&wr_id=2786647) is bold), is also recognized by the H3K4 demethylase KDM1A/LSD1, which is able to removing the methyl mark on most of those substrates 17 , ninety four Subsequently KMT7/KDM1A has emerged as a classic model for dynamic lysine methylation of each histone and non-histone proteins.
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